Despite considerable progress made in therapy and prophylaxis during the last quarter of the century, tuberculosis of various sites continues to be a major health hazard in india. Intestinal tuberculosis masquerading as difficult to treat. Journal mainly focus on clinical research and epidemiological studies on tuberculosis, drug resistance during therapy. Israel journal of chest disease and tuberculosis is established for electronic information management. Misdiagnosis of ileocecal tuberculosisdiagnostic dilemma with. Management of drtb is an evolving strategy, and needs to be adapted through evidencebased. The methods of biopsy include endoscopic gi mucosal biopsy, imageguided percutanous biopsy, endoscopic ultrasound guided biopsy, and surgical open or laparoscopic biopsy. Seventeen cases showed good response to antituberculosis chemotherapy. Tuberculosis is an endemic disease in developing countries with an increasing incidence. This section aims to publish studies looking at all aspects of the prevention, diagnosis and management of tuberculosis and other mycobacterial diseases in humans, including hivassociated tuberculosis, as well as related molecular genetics, pathophysiology, and epidemiology. Tuberculosis is a speciality journal focusing on basic experimental research on tuberculosis, notably on bacteriological, immunological and pathogenesis aspects of the disease.
Kennedy a paper read at the annual convention of the canadian tuberculosis association, in montreal, june, 1940. The main diagnostic dilemma is to differentiate intestinal tuberculosis and crohns disease because a. The evidences of impaired nutrition with emaciation are first seen. Tuberculosis of the gastrointestinal tract and peritoneum. The incidence and severity depends on the prevalence of tb and infection with human immunode. The most downloaded articles from tuberculosis in the last 90 days. Doctor answers on symptoms, diagnosis, treatment, and more. Current research in tuberculosis, indian journal of tuberculosis. Abdominal tb comprises around 5 percent of all cases of tb worldwide.
Introduction even in current era, incidence of tuberculosis remains high in certain parts of the world with more than half of the worlds tuberculosis infected population residing in asia 1. Journal of tuberculosis is also a must read for all medical professionals who are engaged in tuberculosis research. Legal issues around the management of drugresistant tuberculosis drtb are complex and have been addressed in separate documents, guided by evolving health legislation and the constitution of south africa. Tuberculosis tb remains one of the deadliest infectious diseases responsible for millions of deaths annually across the world. Guidelines for clinical and operational management of drugresistant tuberculosis. The impact factor measures the average number of citations received in a particular year by papers published in the journal during the. Gastrointestinal tuberculosis refers to the infection of abdominal organs with mycobacterium tuberculosis. Twentyseven cases of patients with intestinal tuberculosis were reported. Core gene set as the basis of multilocus sequence analysis of the subclass actinobacteridae. Intestinal tuberculosis is a rare presentation in the absence of pulmonary disease and has a wide spectrum of clinical manifestations, mimicking other diseases such as crohns disease or neoplastic diseases. Tubercle bacilli are located intracellularly, grow only intermittently or assume a dormant form under 1. Tuberculous enteritis is a clinical rarity even in immunocompromised patients. Tuberculosis tb still constitutes a major public health challenge due to its high mortality and morbidity rates 1.
The views expressed in documents by named authors are solely the responsibility of those authors. Until within recent years the status of the diagnosis of intestinal tuberculosis was comparable to that of pulmonary tuberculosis twentyfive years ago, when an early diagnosis was the cause of wonderment. Antibiotic treatment for tuberculosis induces a profound. In countries where tuberculosis is endemic or rampant due to poor socioeconomic status, malnu. Jpmi 154 pain, gastrointestinal upset, and change in the bowel habits were the commonest symptoms in our series and were present in 100%, 96%, 84% patients respectively. Surgical management of intestinal tuberculosis in preoperatively. In addition, milk, which contains tuberculi bacteria, may also infect the intestine. Adekambi t, butler wr, hanrahan f, delcher al, drancourt m, and shinnick tm. Management of severe gastrointestinal tuberculosis with injectable. Journal of tuberculosis and therapeutics open access journals. Risk factors for treatment default in close contacts with latent tuberculous infection. This case points out the need for awareness of intestinal tuberculosis in the differential diagnosis of chronic intestinal disease. Lim jh 2000 ultrasound examination of gastrointestinal tract diseases.
The infectious agents responsible for tuberculosis are myco insight into current guidelines and recommendations for this susbacterium tuberculosis, m. Journal articles published by division of tb elimination dtbe authors 2011 dtbe journal articles. Clinical and laboratory features of intestinal tuberculosis. Suspected diagnosis of intestinal tuberculosis can be confirmed with histology, smear, and culture, although each of these tests, individually, has low sensitivity. In intestinal tuberculosis the granulomas are multiple.
Leadership styles affect on the employee performance and productivity. Top 21 on intestinal tuberculosis contagious healthtap. Gastrointestinal tuberculosis tb may result in intestinal obstruction and perforation, even after antituberculous therapy has been initiated. Higher score predicted more likelihood of intestinal tuberculosis. Tuberculous enteritis presenting as smallbowel obstruction. Surgery for abdominal tuberculosis in the present era. The journals main aim is the continuing education of physicians and other health personnel, and the dissemination of the most uptodate information in the field of tuberculosis and lung health. Perhaps fiftyfive per cent of the prolonged cases of pulmonary. The literature on resolution of intestinal strictures in patients with intestinal tuberculosis itb after antituberculous therapy att is sparse and ambivalent. The international journal of tuberculosis and lung disease external icon 2014 apr 1. In this paper we present a general overview of tb including the pathogenesis, diagnosis, and treatment guidelines. Mycobacterium tuberculosis, the cause of tuberculosis tb, infects one third of the worlds population and causes substantial mortality worldwide. In centers where diagnostic facilities are not available, laparotomy is the safest procedure to diagnose as well as manage the intestinal tuberculosis, when present with features of intestinal.
Abdominal tb is generally responsive to medical treatment alone, so early diagnosis can prevent. Main articles welcome to south sudan medical journal. Intestinal tuberculosis in a child living in a country. Each year, tuberculosis tb results in the death of 3 million people globally. But respiratory and intestinal symptoms were present. We present a case of miliary tuberculosis with gastrointestinal involvement. Download the pdf to view the article, as well as its associated figures and tables.
Article pdf available in the american journal of gastroenterology. Italy journal of chest disease and tuberculosis is authenticate source of scholarly communication. Currently, the management is even more complex with the emerging of multi drugresistant bacteria. Despite surgical intervention tuberculous perforation has a high complication and mortality rate, and it is difficult to predict the subgroup of patients with abdominal tb who progress to perforation. A paper read at the annual convention of the canadian tuberculosis association, in montreal, june, 1940. Abdominal tuberculosis of the gastrointestinal tract. Abdominal tuberculosis tb includes involvement of the gastrointestinal tract, peritoneum, lymph nodes, andor solid organs. The international journal of tuberculosis and lung disease is an official journal of the union. Recent retrospective and prospective studies are leading to the development of.
The caseation necrosis in granulomas is the histologic hallmark of tb. Abdominal tb is generally responsive to medical treatment, and early diagnosis and management can prevent unnecessary surgical. Pathophysiology and microbiology of pulmonary tuberculosis. Renewed interest has been awakened in the subject of intestinal. Although culture is the hallmark for diagnosis, it has limitations in patients with active pulmonary tb, for whom swallowed sputum could give falsepositive test results, even with tissue samples. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Clinical and laboratory features of intestinal tuberculosis bhumit patel,1 vipul d yagnik2 1department of medical gastroenterology, akshar bhoomi liver and gastro care, ahmedabad, gujarat, india. The protean manifestations of intestinal tuberculosis mean that the diagnosis is often delayed sometimes even for years, thus leading to increased mortality and unnecessary surgery.
Challenges of tuberculosis management in high and low. Eight per cent of 1,801 consecutive patients at the trudeau sanatorium had definite intestinal tuberculosis. The journal of chest disease and tuberculosis photon. Patients with tuberculosis tb need to be managed appropriately to prevent death and transmission of the disease to other people, and to avoid the emergence of drug resistance. The incidence of intestinal tb in western countries has increased. Guidelines for clinical and operational management of drug. Relatively common in adults, intestinal tuberculosis is considered rare in children and adolescents. Abdominal tuberculosis denotes involvement of the gastrointestinal tract, peritoneum, lymph nodes, and solid viscera, e. A 47yearold homosexual male from philippines with no significant medical history presented with productive cough, night sweats, subjective fevers, shortness of breath, watery diarrhea, and 25pound weight loss in past one year. Fiske ct, yan fx, hirschmoverman y, sterling tr, reichler mr, for the tuberculosis epidemiologic studies consortium task order 2 team. Some strains of mycobacterium tuberculosis are associated with more extrapulmonary disease and greater dissemination, thereby exacerbating the rise in hivassociated extrathoracic tb. Crohn disease has low prevalence in sri lanka while compared to the west, while intestinal tuberculosis is common in the region. Caseation and peritoneal tubercles 103 cases differentiate intestinal tuberculosis from crohns disease. Pharmacists are well placed within multidisciplinary teams to help patients manage their medicines.
Guide for authors indian journal of tuberculosis issn. Treatment of the intestinal tuberculosis springerlink. Most common form of extrapulmonary tuberculosis 3 to 4% defined as tuberculosis infection of the abdomen including gastrointestinal tract, peritoneum, omentum, mesentery and its nodes, liver, spleen and pancreas mycobacterium tuberculosis is the most frequently isolated organism. The ileum and cecum are the most common sites of intestinal involvement and are affected in 75% of cases. Autopsies of patients with pulmonary tb before the era of effective treatment demonstrated intestinal involvement in 5590% of fatal cases. Surgical management of intestinal tuberculosis is a crucial task in preoperatively unsuspected cases. Abdominal tuberculosis tb is generally responsive to medical treatment, and early diagnosis and management can prevent unnecessary. The dietary management of intestinal tuberculosis allan s. National library of medicine, or vancouver style international committee of medical journal editors. A perspective of the diagnosis and management of congenital tuberculosis. Pdf clinical, endoscopic, and histological differentiations. Currently, the management is even more complex with the emerging of multi drug resistant bacteria. Infectious means that it is contagious from one person to another. Leadership and strategic management for tb control managers.
The disease occurs most commonly as a secondary infection in adults, following any other local infection, and especially following pulmonary infection from the swallowing of the saliva and sputum. Introduction tuberculosis, a common disease in india and other developing countries the extrapulmonary tuberculosis involves 1116% of patients, out of which 34% belong to abdominal tuberculosis abdominal tuberculosis is the 6th most common type of extrapulmonary tuberculosis 3. Since clinical, endoscopic and investigation features of crohn disease overlap with intestinal tuberculosis, differentiating these two conditions becomes a dilemma for the clinician in the intestinal tuberculosis endemic setting. The indian journal of tuberculosis, published in india since 1953 onwards, is a quarterly publication january, april, july, october, and is devoted to the specialty of tuberculosis and lung diseases. It is most important for all national tuberculosis programmes ntps that countries have their own nationspecific guidelines to define mdr suspects.
More than 95% of tuberculosis deaths occur in low and middle income countries. Pdf the clinical, endoscopic, and histological features of crohns disease cd and. Intestinal tuberculosis is the most frequent complication of pulmonary tuberculosis and is found in from 50 to 80 per cent or even more of all autopsies performed on patients who have died from pulmonary tuberculosis. The numbers and size of ulceration, pseudopolyp and deformity of intestinal tract were checked by endoscopic and xray studies on comparative evaluation between prechemotherapeutic and postchemotherapeutic stage. Intestinal tuberculosis frequently complicates lung infections with tuberculosis. This journal is the official organ of the tuberculosis association of india,a voluntary organization, engaged in the fight against tb since 1939. Lazarus, md, facp, fccp and bennett thilagar, md introduction tuberculosis tb can involve the entire gastrointestinal tract gi including the peritoneum and the pancreatobiliary system. Tuberculosis is primarily a lung infection, but it can infect other areas of the body as well. Diagnosis of abdominal tuberculosis world journal of emergency. Journal of gastrointestinal oncology journal of hospital management and. Both sides of the ileocecal valve usually are introduction tuberculosis is a disease which. Editor international union against tuberculosis and lung disease the union 68 boulevard st michel, 75006 paris, france suggested citation caminero ja, ed.